六烯酸
成对比较
二十碳五烯酸
随机对照试验
荟萃分析
内科学
医学
化学
多不饱和脂肪酸
统计
数学
生物化学
脂肪酸
作者
Somaye Fatahi,Mohammad Hassan Sohouli,Elma Izze da Silva Magalhães,Victor Nogueira da Cruz Silveira,Fernando Zanghelini,Parisa Rahmani,Hamed Kord‐Varkaneh,Elham Sharifi-Zahabi,Farzad Shidfar
标识
DOI:10.1016/j.numecd.2022.09.013
摘要
BackgroundEvidence from clinical trial studies suggests that docosahexaenoic acids (DHA) may have greater potential effects on improving cardiovascular risk factors than eicosapentaenoic acid (EPA). However, this evidence has not yet been meta-analyzed and quantified. The aim of this study was to evaluate and compare the effect of DHA and EPA monotherapy on cardiovascular risk factors based on paired and network meta-analysis.MethodsRelevant articles published up to January 2022 were systematically retrieved from relevant databases. We included all Randomized Controlled Trials (RCTs) on adults that directly compared the effects of DHA with EPA and RCTs of indirect comparisons (DHA and EPA monotherapy compared to control groups). Data were pooled by pairwise and network meta-analysis and expressed as mean differences (MDs) with 95% CIs. The study protocol was registered with PROSPERO (Registration ID: CRD42022328630).ResultsNetwork meta-analysis of comparisons of DHA and EPA suggested significant comparable effects only on LDL-C (MD EPA versus DHA = −8.51 mg/L; 95% CI: −16.67; −0.35). However, the Network meta-analysis not show a significant effect for other risk factors. Furthermore, pairwise meta-analysis of direct comparisons of DHA and EPA showed significant difference in their effects on plasma glucose (MD EPA versus DHA = −0.31 mg/L; 95% CI: −0.60, −0.02), Insulin (MD EPA versus DHA = −2.14 mg/L; 95% CI: −3.26, −1.02), but the results were not significant for risk factors.ConclusionOur findings suggest that both EPA and DHA act similarly on the markers under study, with slight changes in plasma glucose, insulin, and LDL-C.
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