Who Benefits More From IBMS or Qigong? Clinical Data-Mining RCT Data

Purpose: A recent three-arm randomized controlled trial (RCT) with depressed Hong Kong adults demonstrated the comparable effectiveness of integrative Body-Mind-Spirt (IBMS) and Qigong interventions in relieving sleep disturbance and depression, but not which is best for whom? Guided by concept and theory-based hypotheses, clinical data-mining (CDM), the RCT data answers the more clinically relevant question: who responds best to which intervention? Method: Paired-sample t-tests and Wilcoxon signed-ranked tests were adopted to compare the within-subgroup differences; linear mixed models for normally distributed outcomes and generalized linear mixed models for non-normally distributed outcomes were used to compare the between-subgroup differences. Results: Results indicate that IBMS is more efficacious for older, more educated females, suffering from physical pain and illness; whereas younger, less educated males, not in full-time employment benefit more from Qigong. Discussion: This productive joining together of RCT and CDM recommends itself to both past and future RCTs, further informing evidence-based practice decision making.