化学
区域选择性
分子内力
光催化
反应性(心理学)
激进的
分子
氢键
小学(天文学)
催化作用
组合化学
氮原子
氢原子
光化学
立体化学
有机化学
群(周期表)
光催化
物理
病理
医学
替代医学
天文
作者
Xi Chen,Zhe Zhang,Wei‐Yu Shi,Yanan Ding,Yu‐Yong Luan,Yan‐Chong Huang,Q.-G. Wang,Xue-Yuan Liu,Yong‐Min Liang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-06-09
卷期号:25 (24): 4456-4461
被引量:4
标识
DOI:10.1021/acs.orglett.3c01361
摘要
We report a redox-neutral, visible-light-mediated difluoroalkylation of unactivated C(sp3)-H bonds in amides via nitrogen-centered radicals triggered intramolecular hydrogen atom transfer. Notably, all types (tertiary, secondary, and primary) of γ-C(sp3)-H bonds displayed excellent reactivity. This methodology presents a facile route for the regioselective introduction of α,α-difluoroketone fragments into organic molecules. Moreover, the resulting gem-difluoroketones can be readily converted to structurally diverse difluoro-containing molecules, offering broad potential applications in medicinal chemistry and chemical biology.
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