免疫疗法
癌症
癌症免疫疗法
免疫系统
医学
免疫原性
癌症疫苗
免疫学
癌细胞
癌症研究
内科学
作者
Xiaoyuan Fan,Kaiyuan Wang,Qing Lü,Yutong Lu,Jin Sun
出处
期刊:Small
[Wiley]
日期:2022-11-27
卷期号:19 (4)
被引量:9
标识
DOI:10.1002/smll.202205166
摘要
Immunotherapy aims to activate the cancer patient's immune system for cancer therapy. The whole process of the immune system against cancer referred to as the "cancer immunity cycle", gives insight into how drugs can be designed to affect every step of the anticancer immune response. Cancer immunotherapy such as immune checkpoint inhibitor (ICI) therapy, cancer vaccines, as well as small molecule modulators has been applied to fight various cancers. However, the effect of immunotherapy in clinical applications is still unsatisfactory due to the limited response rate and immune-related adverse events. Mounting evidence suggests that cell-based drug delivery systems (DDSs) with low immunogenicity, superior targeting, and prolonged circulation have great potential to improve the efficacy of cancer immunotherapy. Therefore, with the rapid development of cell-based DDSs, understanding their important roles in various stages of the cancer immunity cycle guides the better design of cell-based cancer immunotherapy. Herein, an overview of how cell-based DDSs participate in cancer immunotherapy at various stages is presented and an outlook on possible challenges of clinical translation and application in future development.
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