前脑
生物
斑马鱼
神经科学
小胶质细胞
生物神经网络
表型
微生物群
自闭症
中枢神经系统
炎症
免疫学
心理学
遗传学
基因
发展心理学
作者
Joseph J. Bruckner,Sarah J Stednitz,Max Z. Grice,Dana Zaidan,Michelle S. Massaquoi,Johannes Larsch,Alexandra Tallafuss,Karen Guillemin,Philip Washbourne,Judith S. Eisen
出处
期刊:PLOS Biology
[Public Library of Science]
日期:2022-11-01
卷期号:20 (11): e3001838-e3001838
标识
DOI:10.1371/journal.pbio.3001838
摘要
Host-associated microbiotas guide the trajectory of developmental programs, and altered microbiota composition is linked to neurodevelopmental conditions such as autism spectrum disorder. Recent work suggests that microbiotas modulate behavioral phenotypes associated with these disorders. We discovered that the zebrafish microbiota is required for normal social behavior and reveal a molecular pathway linking the microbiota, microglial remodeling of neural circuits, and social behavior in this experimentally tractable model vertebrate. Examining neuronal correlates of behavior, we found that the microbiota restrains neurite complexity and targeting of forebrain neurons required for normal social behavior and is necessary for localization of forebrain microglia, brain-resident phagocytes that remodel neuronal arbors. The microbiota also influences microglial molecular functions, including promoting expression of the complement signaling pathway and the synaptic remodeling factor c1q . Several distinct bacterial taxa are individually sufficient for normal microglial and neuronal phenotypes, suggesting that host neuroimmune development is sensitive to a feature common among many bacteria. Our results demonstrate that the microbiota influences zebrafish social behavior by stimulating microglial remodeling of forebrain circuits during early neurodevelopment and suggest pathways for new interventions in multiple neurodevelopmental disorders.
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