机制(生物学)
表观遗传学
甲基化
炎症
发病机制
生物标志物
N6-甲基腺苷
DNA甲基化
RNA甲基化
生物
生物信息学
医学
免疫学
遗传学
基因
基因表达
甲基转移酶
认识论
哲学
作者
Quandan Tan,Song He,Xinyi Leng,Danni Zheng,Fengkai Mao,Junli Hao,Kejie Chen,Hongzhi Jiang,Yapeng Lin,Jie Yang
摘要
N6-methyladenosine (m6A) modification is a newly discovered regulatory mechanism in eukaryotes. As one of the most common epigenetic mechanisms, m6A’s role in the development of atherosclerosis (AS) and atherosclerotic diseases (AD) has also received increasing attention. Herein, we elucidate the effect of m6A on major risk factors for AS, including lipid metabolism disorders, hypertension, and hyperglycemia. We also describe how m6A methylation contributes to endothelial cell injury, macrophage response, inflammation, and smooth muscle cell response in AS and AD. Subsequently, we illustrate the m6A-mediated aberrant biological role in the pathogenesis of AS and AD, and analyze the levels of m6A methylation in peripheral blood or local tissues of AS and AD, which helps to further discuss the diagnostic and therapeutic potential of m6A regulation for AS and AD. In summary, studies on m6A methylation provide new insights into the pathophysiologic mechanisms of AS and AD, and m6A methylation could be a novel diagnostic biomarker and therapeutic target for AS and AD.
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