生物
叶绿体
基因组
叶绿体DNA
拟南芥
细胞生物学
DNA复制
细胞器
细胞核
核运输
遗传学
DNA
突变体
基因
核心
作者
Honglei Jin,Sujuan Duan,Pengxiang Zhang,Ziyue Yang,Yunping Zeng,Ziqi Chen,Liu Hong,Mengshu Li,Lujun Luo,Zhenyi Chang,Jiliang Hu,Hong-Bin Wang
出处
期刊:Cell Reports
[Elsevier]
日期:2023-03-01
卷期号:42 (3): 112268-112268
标识
DOI:10.1016/j.celrep.2023.112268
摘要
The coordination of chloroplast and nuclear genome status is critical for plant cell function. Here, we report that Arabidopsis CHLOROPLAST AND NUCLEUS DUAL-LOCALIZED PROTEIN 1 (CND1) maintains genome stability in the chloroplast and the nucleus. CND1 localizes to both compartments, and complete loss of CND1 results in embryo lethality. Partial loss of CND1 disturbs nuclear cell-cycle progression and photosynthetic activity. CND1 binds to nuclear pre-replication complexes and DNA replication origins and regulates nuclear genome stability. In chloroplasts, CND1 interacts with and facilitates binding of the regulator of chloroplast genome stability WHY1 to chloroplast DNA. The defects in nuclear cell-cycle progression and photosynthesis of cnd1 mutants are respectively rescued by compartment-restricted CND1 localization. Light promotes the association of CND1 with HSP90 and its import into chloroplasts. This study provides a paradigm of the convergence of genome status across organelles to coordinately regulate cell cycle to control plant growth and development.
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