Application of antibiotic-loaded bone cement in treating lower limb soft tissue infection

Objective: To explore the clinical efficacy of antibiotic-loaded bone cement in the treatment of lower limb soft tissue infection. Methods: A retrospective analysis was carried out on 40 patients with lower limb soft tissue infection who were admitted to Sichuan Orthopedic Hospital from January 1, 2022 to December 1, 2023. The enrolled patients were divided into two groups according to different therapies, including the bone cement treatment (the study group) group and the conventional treatment group (the control group), with 20 cases in each group. Further comparison was made on the number of operations, wound healing time, Grade-A wound healing rate, recurrence rate, and recovery rate of inflammatory indicators between the two groups. Results: Patients in both groups were followed up, and there was no statistically significant difference in the number of operations between the two groups (P>0.05). The study group had shorter wound healing time (P<0.05), higher Grade-A wound healing rate (P<0.05), lower recurrence rate (P<0.05), and higher normal rate of inflammatory indicators (P<0.05) than those in the control group. Conclusion: Antibiotic-loaded bone cement showed a clear effect on treating lower limb soft tissue infection, with good wound healing and low recurrence rate. doi: https://doi.org/10.12669/pjms.41.3.9872 How to cite this: Lang Z, Zhang X, Liang Y. Application of antibiotic-loaded bone cement in treating lower limb soft tissue infection. Pak J Med Sci. 2025;41(3):792-797. doi: https://doi.org/10.12669/pjms.41.3.9872 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.