脂肪变性
脂肪性肝炎
脂肪肝
内分泌学
内科学
胰岛素抵抗
肝星状细胞
生物
医学
胰岛素
疾病
作者
Danyan Zhang,Ayiguzhali Abulitipu,Pengcheng Pang,Lei Bai,Rui Li,Shaliyan Tuerxunmaimaiti,Wen Chen,Shuangfeng Chen,Houkun Lv,Yadong Fu,Qizhen Du,Fuquan Jin,Chunyan Yi,Yangmin Hao,Liyan Ma,Jingsong Li,Zhiyang Ling,Yaguang Zhang,Liang Zhao,Weiguo Fan
出处
期刊：Hepatology
[Lippincott Williams & Wilkins]
日期：2025-05-15
卷期号：83 (3): 603-622
被引量：7
标识
DOI：10.1097/hep.0000000000001402
摘要
Our study reveals that ECM1 is a critical regulator in MASH, modulating lipid peroxidation by maintaining PCBP1-mediated intracellular iron homeostasis. Targeting ECM1 to restore PCBP1-dependent iron homeostasis may offer a novel therapeutic avenue for MASH.
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(2025-6-4)
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