A novel STAT3 CCD inhibitor for suppressing macrophage activation and lipopolysaccharide-induced acute lung injury

Signal transducer and activator of transcription 3 (STAT3) has a crucial role in inflammation in lipopolysaccharide (LPS)-induced acute lung injury (ALI). The current study aimed at developing a novel STAT3 coiled-coil domain (CCD) inhibitor for suppression of inflammatory response in LPS-induced ALI.