基质金属蛋白酶
药物输送
基质金属蛋白酶9
药品
纳米颗粒
化学
基质金属蛋白酶抑制剂
医学
药理学
癌症研究
纳米技术
材料科学
生物化学
有机化学
作者
Liang Zong,Hongliang Xu,Huiqi Zhang,Ziwei Tu,Xiao Zhang,Shumin Wang,Meigui Li,Yan Feng,Bin Wang,L Li,Xinmei Xie,He Zhang,Xiaohui Pu
标识
DOI:10.1016/j.ijbiomac.2024.130043
摘要
Matrix metalloproteinase-2 (MMP-2)-responsive nanodrug vehicles have garnered significant attention as antitumor drug delivery systems due to the extensive research on matrix metalloproteinases (MMPs) within the tumor extracellular matrix (ECM). These nanodrug vehicles exhibit stable circulation in the bloodstream and accumulate specifically in tumors through various mechanisms. Upon reaching tumor tissues, their structures are degraded in response to MMP-2 within the ECM, resulting in drug release. This controlled drug release significantly increases drug concentration within tumors, thereby enhancing its antitumor efficacy while minimizing side effects on normal organs. This review provides an overview of MMP-2 characteristics, enzyme-sensitive materials, and current research progress regarding their application as MMP-2-responsive nanodrug delivery system for anti-tumor drugs, as well as considering their future research prospects. In conclusion, MMP-2-sensitive drug delivery carriers have a broad application in all kinds of nanodrug delivery systems and are expected to become one of the main means for the clinical development and application of nanodrug delivery systems in the future.
科研通智能强力驱动
Strongly Powered by AbleSci AI