Synergistic activity of copper and molybdenum based organic frameworks for the exceptional electrochemical detection of rifampicin in commercial dairy products

A highly sensitive electrochemical sensor was developed by modifying the glassy carbon electrode (GCE) using bimetal organic frameworks, Cu-Mo MOFs, synthesized by a facile hydrothermal method, for the detection of rifampicin (RIF). The as prepared material was analyzed using, X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), transmission electron microscope (TEM) and X-ray photoelectron spectroscopy (XPS). The Cu-Mo MOFs/GCE was characterized by various electro analytical methods such as electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and differential pulse voltammetry (DPV) under the optimal conditions (pH 7.0). The effective surface area of 0.00728 cm2, and low charge transfer resistance results in the enhanced performance of the developed sensor. The Cu-Mo MOFs/GCE showed low LOD of 0.14 µM and LOQ of 0.435 µM over the range of 0.5 µM–150 µM. The modified GCE has robust stability showing the RSD value of 2.56 % and good reproducibility. The electrochemical performance might be attributed to good stability, selectivity, and sensitivity towards the detection of RIF. It could be effectively used for the sensitive detection of RIF in real sample.