小RNA
威尔姆斯瘤
发病机制
肾脏疾病
癌症研究
多囊肾病
疾病
肾
生物
肾脏发育
生物信息学
医学
基因
病理
免疫学
遗传学
内分泌学
胚胎干细胞
标识
DOI:10.1016/j.prp.2024.155254
摘要
Wilms' tumors (WTs) are the most common type of kidney tumor in children, and a negative outlook is generally associated with widespread anaplastic. MicroRNAs (miRNAs) are crucial in the development of WT by regulating the expression of specific genes. There is an increasing amount of research that connects the dysregulation of miRNAs to the development of various renal illnesses. The conditions encompassed are renal fibrosis, renal cancers, and chronic and polycystic kidney disease. Dysregulation of several important miRNAs, either oncogenic or tumor-suppressing, has been found in WT. The present state of knowledge on the involvement of dysregulated miRNAs in the progression of WT is summarized in this review.
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