医学
放射治疗
放射治疗计划
医学物理学
放射肿瘤学
影像引导放射治疗
分子成像
精密医学
临床实习
模态(人机交互)
肿瘤缺氧
医学影像学
模式
放射科
病理
人工智能
社会科学
生物技术
家庭医学
社会学
生物
体内
计算机科学
作者
Roberto García‐Figueiras,Sandra Baleato-González,Antonio Luna Alcalá,Anwar R. Padhani,Joan C. Vilanova,Ana M. Carballo-Castro,Laura Oleaga,Juan Antonio Vallejo-Casas,Ana Marhuenda,Antonio Gómez-Caamaño
出处
期刊:Radiographics
[Radiological Society of North America]
日期:2024-02-01
卷期号:44 (2)
摘要
Radiation therapy is fundamental in the treatment of cancer. Imaging has always played a central role in radiation oncology. Integrating imaging technology into irradiation devices has increased the precision and accuracy of dose delivery and decreased the toxic effects of the treatment. Although CT has become the standard imaging modality in radiation therapy, the development of recently introduced next-generation imaging techniques has improved diagnostic and therapeutic decision making in radiation oncology. Functional and molecular imaging techniques, as well as other advanced imaging modalities such as SPECT, yield information about the anatomic and biologic characteristics of tumors for the radiation therapy workflow. In clinical practice, they can be useful for characterizing tumor phenotypes, delineating volumes, planning treatment, determining patients' prognoses, predicting toxic effects, assessing responses to therapy, and detecting tumor relapse. Next-generation imaging can enable personalization of radiation therapy based on a greater understanding of tumor biologic factors. It can be used to map tumor characteristics, such as metabolic pathways, vascularity, cellular proliferation, and hypoxia, that are known to define tumor phenotype. It can also be used to consider tumor heterogeneity by highlighting areas at risk for radiation resistance for focused biologic dose escalation, which can impact the radiation planning process and patient outcomes. The authors review the possible contributions of next-generation imaging to the treatment of patients undergoing radiation therapy. In addition, the possible roles of radio(geno)mics in radiation therapy, the limitations of these techniques, and hurdles in introducing them into clinical practice are discussed. ©RSNA, 2024 Test Your Knowledge questions for this article are available in the supplemental material.
科研通智能强力驱动
Strongly Powered by AbleSci AI