An Insight Into Adipose Tissue Thermogenesis Regulated by N 6 ‐Methyladenosine: Mechanisms and Therapeutic Implications

ABSTRACT Adipose tissue thermogenesis, both uncoupling protein 1 (UCP1)‐dependent and independent thermogenesis, plays a critical role in the homeostasis of whole‐body metabolism. Emerging evidence demonstrates that key nodes in adipose tissue thermogenesis can be regulated by dynamic and reversible N 6 ‐methyladenosine (m 6 A) modification, which is one of the most prevalent and extensively studied RNA modifications. Furthermore, its dysregulation drives the pathogenesis of obesity and related metabolic disorders. In this review, we elucidate the role and molecular mechanisms of m 6 A modification in adipose tissue thermogenesis, highlight potential therapeutic strategies for promoting thermogenic remodeling of adipose tissue through targeting m 6 A modification, and discuss future research directions in this field. The insights provide clues for translational research aimed at developing m 6 A‐based therapies for metabolic diseases.