PI3K/AKT/mTOR通路
蛋白激酶B
脂多糖
信号转导
肺炎
医学
药理学
化学
生物
细胞生物学
免疫学
内科学
作者
Yanyan Zhang,Dayi Liang,Lailai Li,Yilian Tang,Chen Zhang,Yuexing Li,Liyan Zhang,Xiang Pu
标识
DOI:10.1016/j.jep.2025.120303
摘要
RLQ effectively protected against LPS-induced lung and alveolar epithelial cell injury by inhibiting PI3K/AKT/mTOR pathway phosphorylation, restoring the Treg/Th17 immune balance, and suppressing apoptosis. These findings provide new mechanistic insights into the therapeutic potential of RLQ in the treatment of pneumonia.
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