Downregulation of Mg 2+ Efflux Protein CNNM3 Predicts Poor Prognosis but Enhances Ferroptosis Sensitivity in Kidney Renal Clear Cell Carcinoma via NCOA4‐Mediated Ferritinophagy

" homeostatic mechanism in KIRC cells, with CNNM3 serving as a critical regulatory component. The findings of the present study offer a new direction for further research, with the potential to develop novel and effective therapeutic strategies for KIRC patients exhibiting CNNM3 low expression and unfavorable clinical outcomes. The therapeutic targeting of ferroptosis may present a viable treatment approach for patients with KIRC who exhibit low CNNM3 expression and poor clinical outcomes.