Diversity of the gut-microbiome related to cognitive behavioral outcomes in healthy older adults

With the aging of the United States population, age-related cognitive disorders will be more prevalent and will negatively impact society. Differences in factors within and among individuals that influence cognitive decline complicate studies on the topic. One difference among individuals - gut microbiome diversity and composition - changes within the person across their lifespan and varies among individuals. An individual's gut microflora can significantly influence gut-brain communication, brain function, and behavior. Little research has been done to evaluate the gut-brain relation in non-clinical populations, with no previous studies, to our knowledge, in healthy older adults. In the present study, we investigated the relation between microbiome diversity and cognitive decline. The researchers invited sixty-three healthy older adults between 67-83 years of age to provide a fecal sample and complete an electrophysiological assessment of brain potentials (Event-Related Potentials; ERP) and the Cambridge Neuropsychological Test Automated Battery (CANTAB). Electrophysiological and behavioral data were related to alpha diversity, a measure of the variety of species in the gut-microbiome, supporting the hypothesis that a relation exists between gut microbial diversity and cognitive performance in healthy older adults as measured by CANTAB and ERP. To our knowledge, this study is the first to demonstrate the association between ERP outcomes and the gut-microbiome. Our results begin to bridge the gap in our understanding of the connection between behavior and the composition of the gut-microbiome, commonly referred to as the gut-brain connection.