广藿香
兰克尔
骨质疏松症
去卵巢大鼠
受体
医学
刺蕊草属
药理学
破骨细胞
TLR4型
内科学
孕烷X受体
激活剂(遗传学)
化学
内分泌学
核受体
转录因子
传统医学
生物化学
雌激素
替代医学
病理
基因
作者
Qian Lü,Chao Jiang,Jialong Hou,Haoliang Qian,Feifan Chu,Weiqi Zhang,Mengke Ye,Ziyi Chen,Jian Liu,Han-Bing Yao,Jianfeng Zhang,Jiake Xu,Te Wang,Shunwu Fan,Qingqing Wang
标识
DOI:10.3389/fphar.2021.684976
摘要
The incidence of osteoporosis, which is primarily characterized by plethoric osteoclast (OC) formation and severe bone loss, has increased in recent years. Millions of people worldwide, especially postmenopausal women, suffer from osteoporosis. The drugs commonly used to treat osteoporosis still exist many disadvantages, but natural extracts provide options for the treatment of osteoporosis. Therefore, the identification of cost-effective natural compounds is important. Patchouli alcohol (PA), a natural compound extracted from Pogostemon cablin that exerts anti-inflammatory effects, is used as a treatment for gastroenteritis. However, no research on the use of Patchouli alcohol in osteoporosis has been reported. We found that PA dose-dependently inhibited the receptor activator of nuclear factor kappa-B ligand (RANKL)-induced formation and function of OCs without cytotoxicity. Furthermore, these inhibitory effects were reflected in the significant effect of PA on the NF-κB signaling pathway, as PA suppressed the transcription factors NFATc1 and c-Fos. We also determined that PA activated expression of the nuclear receptor pregnane X receptor (PXR) and promoted the PXR/Toll-like receptor 4 (TLR4) axis to inhibit the nuclear import of NF-κB (p50 and p65). Additionally, PA exerted therapeutic effects against osteoporosis in ovariectomized (OVX) mice, supporting the use of PA as a treatment for osteoporosis in the future.
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