蛋白激酶C
基因亚型
功能(生物学)
蛋白质组
激酶
细胞生物学
计算生物学
生物
药物靶点
生物信息学
遗传学
药理学
基因
作者
Alastair W. Poole,Giordano Pula,Ingeborg Hers,David Crosby,Matthew L. Jones
标识
DOI:10.1016/j.tips.2004.08.006
摘要
Protein kinase C (PKC) is a ubiquitously expressed family of kinases that have key roles in regulating multiple cellular activities. The activity of this family is controlled tightly by several molecular mechanisms, including interaction with binding-partner proteins. These PKC-interacting proteins (C-KIPs) confer specificity for individual PKC isoforms by regulating the activity and cellular localization of PKC isoforms and, subsequently, the ability of these isoforms to specifically regulate cellular functional events. Although many C-KIPs have been identified by genome and proteome-mining approaches, it is important to address the specificity and function of the interactions in greater detail because they might form novel drug targets. In this article, we review recent work on C-KIPs and the implications for pharmacological and therapeutic development.
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