谷氨酸的
药物发现
谷氨酸受体
谷氨酸羧肽酶Ⅱ
药理学
神经科学
化学
计算生物学
医学
生物
生物化学
内科学
受体
癌症
前列腺
作者
Takashi Tsukamoto,Krystyna M. Wozniak,Barbara S. Slusher
标识
DOI:10.1016/j.drudis.2007.07.010
摘要
During the past 10 years, substantial progress has been made in the discovery and development of small molecule glutamate carboxypeptidase II (GCP II) inhibitors. These inhibitors have provided the necessary tools to investigate the physiological role of GCP II as well as the potential therapeutic benefits of its inhibition in neurological disorders of glutamatergic dysregulation. This review article details key GCP II inhibitors discovered in the last decade and important findings from preclinical and clinical studies.
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