Semaphorin 7A aggravates abdominal aortic aneurysm through PDK1/SGK3/YTHDC1 axis-mediated phenotypic switching of vascular smooth muscle cells

This study underscores the critical role of SEMA7A in regulating VSMC phenotypic switching through a novel PDK1/SGK3/YTHDC1 axis, which contributes to AAA pathogenesis, suggesting that targeting SEMA7A is a promising therapeutic strategy for AAA prevention and treatment.