Effect of Diazoxide Treatment on 7 Children with Congenital Hyperinsulinism

Objective To analyze the effect of diazoxide treatment on children with congenital hyperinsulinism(CHI).Methods Clinical data of 7 children (male 5 cases,female 2 cases;aged from 2 days to 4 months;birth weight 2.65-4.60 kg) with CHI hospitalized in Beijing Children′s Hospital from 2006 to 2008 were analyzed retrospectively and the treatment methods and effects of diazoxide on CHI were eva-luated.Results Of the 7 children who were studied,blood glucose of 5 cases recovered to normal level gradually after using diazoxide,indicated that these 5 children respond to treatment of diazoxide.Two cases still showed seriously hypoglycemia after using diazoxide for 10 days,which indicated that 2 children had no reaction to diazoxide.Conclusions Because of having normal functional KATP channel,partial patients with CHI will respond to treatment of diazoxide.Thus,diazoxide should be used as a trial immediately after CHI diagnosis was made.