Pharmacokinetics and bioequivalence of torasemide capsules and tablets in healthy volunteers

OBJECTIVE To study the pharmacokinetics and bioequivalence of torasemide test capsules and reference tablets in healthy volunteers.METHODSA single oral dose of 10mg the test or the reference preparation was given to 20 healthy volunteers in a randomized two-period crossover study.HPLC-UV was performed to detect torasemide with furosemide as the internal standard(IS).RESULTSThe main pharmacokinetic parameters of test capsules and reference tablets were as follows:Cmax were(1 160.1±188.0)and(1 271.2±326.8)μg· L-1;Tmax were(1.1±0.4)and(1.0±0.4)h;t1/2 were(4.1±1.0)and(4.0±1.0)h;AUC0→t were(3 662.3±782.2)and(3 783.2±1 390.1)μg·h·L-1,respectively.The relative bioavalability of the test capsules was(100.6±23.9)%.CONCLUSIONThe results show that the test capsules of torasemide and the reference tabtets are bioequivalent.