Multi-domain modeling and simulation is needed for mechatronic system development.Modelica is a object-oriented physical modeling language for complex physical system modeling and simulation,and the platform of Dymola which fully supports the Modelica language makes the simulation easier.Drive screw is one of classic mechatronic systems,whose modeling and simulation is implemented in Modelica language under Dymola environment.Simulation results showed that the servo-system of drive screw's dynamic performance was fine,and it was proved by experiment.Modelica/Dymola combines mechanical,electrical and control system seamlessly and makes the modeling more vivid.