生长素
内分泌学
内科学
餐后
背景(考古学)
产矿性
医学
神经性贪食症
神经性厌食
胃轻瘫
暴食
肥胖
胃排空
激素
饮食失调
糖尿病
生物
胃
神经肽
受体
神经肽Y受体
精神科
古生物学
作者
Maria Nunez‐Salces,Hui Li,Christine Feinle‐Bisset,Richard L. Young,Amanda J. Page
摘要
Abstract Ghrelin is a gastric hormone with multiple physiological functions, including the stimulation of food intake and adiposity. It is well established that circulating ghrelin levels are closely associated with feeding patterns, rising strongly before a meal and lowering upon food intake. However, the mechanisms underlying the modulation of ghrelin secretion are not fully understood. The purpose of this review is to discuss current knowledge on the circadian oscillation of circulating ghrelin levels, the neural mechanisms stimulating fasting ghrelin levels and peripheral mechanisms modulating postprandial ghrelin levels. Furthermore, the therapeutic potential of targeting the ghrelin pathway is discussed in the context of the treatment of various metabolic disorders, including obesity, type 2 diabetes, diabetic gastroparesis and Prader‐Willi syndrome. Moreover, eating disorders including anorexia nervosa, bulimia nervosa and binge‐eating disorder are also discussed.
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