程序性细胞死亡
细胞生物学
转录因子
生物
效应器
细胞凋亡
GPX4
氧化应激
生物化学
基因
遗传学
谷胱甘肽过氧化物酶
过氧化氢酶
作者
Annadurai Anandhan,Matthew Dodson,Cody J. Schmidlin,Pengfei Liu,Donna D. Zhang
标识
DOI:10.1016/j.chembiol.2020.03.011
摘要
Ferroptosis is a non-apoptotic mode of regulated cell death that is iron and lipid peroxidation dependent. As new mechanistic insight into ferroptotic effectors and how they are regulated in different disease contexts is uncovered, our understanding of the physiological and pathological relevance of this mode of cell death continues to grow. Along these lines, a host of pharmacological modulators of this pathway have been identified, targeting proteins involved in iron homeostasis; the generation and reduction of lipid peroxides; or cystine import and glutathione metabolism. Also, of note, many components of the ferroptosis cascade are target genes of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2), indicating its critical role in mediating the ferroptotic response. In this review, we discuss the in vitro, in vivo, and clinical evidence of ferroptosis in disease, including a brief discussion of targeting upstream mediators of this cascade, including NRF2, to treat ferroptosis-driven diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI