Chemical Investigation Of Secondary Metabolites Produced By Mangrove Endophytic Fungus Phyllosticta Capitalensis

Chemical investigation of endophytic fungus Phyllosticta capitalensis, isolated from the hypocotyls of the Chinese mangrove Bruguiera sexangula led to the isolation of eight known secondary metabolites, including four meroterpenes guignardone A (1), 12-hydroxylated guignardone A (2), guignardone J (3), guignardone M (4), and four polyketides xenofuranone B (5), 6,8-dihydroxy-5-methoxy-3-methyl-1H-isochromen-1-one (6), regiolone (7), 3,4-dihydroxybenzoic acid (8). Their structures were elucidated unambiguously based on the comprehensive spectroscopic analysis and comparison with literature data. This is the first report of these compounds being isolated from this fungal species. All compounds isolated were subjected to antimicrobial and cytotoxic activities evaluation.