肺癌
上皮-间质转换
转移
癌症研究
生物
长非编码RNA
医学
肺癌的治疗
癌症
串扰
肿瘤科
生物信息学
核糖核酸
内科学
基因
遗传学
物理
光学
作者
Milad Ashrafizadeh,Muhammad Shahinozzaman,Sima Orouei,Vahideh Zarrin,Kiavash Hushmandi,Farid Hashemi,Anuj Kumar,Saeed Samarghandian,Masoud Najafi,Ali Zarrabi
出处
期刊:Current Cancer Drug Targets
[Bentham Science]
日期:2021-08-01
卷期号:21 (8): 640-665
被引量:24
标识
DOI:10.2174/1568009621666210203110305
摘要
Lung cancer has the first place among cancer-related deaths worldwide and demands novel strategies in the treatment of this life-threatening disorder. The aim of this review is to explore the regulation of epithelial-to-mesenchymal transition (EMT) by long non-coding RNAs (lncRNAs) in lung cancer.LncRNAs can be considered as potential factors for targeting in cancer therapy, since they regulate a bunch of biological processes, e.g. cell proliferation, differentiation and apoptosis. The abnormal expression of lncRNAs occurs in different cancer cells. On the other hand, epithelial-to-mesenchymal transition (EMT) is a critical mechanism participating in migration and metastasis of cancer cells.Different databases, including Google Scholar, Pubmed and Science direct, were searched for collecting articles using keywords such as "LncRNA", "EMT", and "Lung cancer".There are tumor-suppressing lncRNAs that can suppress EMT and metastasis of lung cancer cells. Expression of such lncRNAs undergoes down-regulation in lung cancer progression and restoring their expression is of importance in suppressing lung cancer migration. There are tumor- promoting lncRNAs triggering EMT in lung cancer and enhancing their migration.LncRNAs are potential regulators of EMT in lung cancer, and targeting them, both pharmacologically and genetically, can be of importance in controlling the migration of lung cancer cells.
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