免疫系统
免疫学
铜绿假单胞菌
脂多糖
呼吸道
生物
先天免疫系统
鞭毛蛋白
炎症
微生物学
呼吸系统
细菌
遗传学
解剖
作者
Jeanne Bigot,Loïc Guillot,Juliette Guitard,Manon Ruffin,Harriet Corvol,Michel Chignard,Christophe Hennequin,Viviane Balloy
标识
DOI:10.1093/infdis/jiz569
摘要
Abstract Human bronchial epithelial cells play a key role in airway immune homeostasis. We hypothesized that these sentinel cells can remember a previous contact with pathogen compounds and respond nonspecifically to reinfection, a phenomenon called innate immune memory. We demonstrated that their pre-exposure to Pseudomonas aeruginosa flagellin modify their inflammatory response to a second, non-related stimulus, including live pathogens or lipopolysaccharide. Using histone acetyltransferase and methyltransferase inhibitors, we showed that this phenomenon relied on epigenetic regulation. This report is a major breakthrough in the field of multi-microbial respiratory tract infections, wherein control of inflammatory exacerbations is a major therapeutic issue.
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