姜黄素
染色体易位
细胞生长
胰腺癌
细胞
癌症研究
癌症
细胞迁移
癌细胞
生物
基因表达
小RNA
化学
基因
细胞生物学
药理学
生物化学
遗传学
作者
Junjian Li,Qi Xu,Chonglin Tao
出处
期刊:Current Topics in Nutraceutical Research
[New Century Health Publishers LLC]
日期:2020-01-09
卷期号:18 (3): 236-240
标识
DOI:10.37290/ctnr2641-452x.18:236-240
摘要
In this study, we investigated the role of curcumin in pancreatic cancer through the regulation of miR-21-5p. We first evaluated the expression of miR-21-5p in pancreatic cancer cells (ASPC-1) treated with different concentrations of curcumin. The results showed that curcumin effectively inhibited the expression of miR-21-5p in ASPC-1 cells in a dose-dependent manner. B cell translocation gene 2 was identified as a target gene of miR-21-5p. MiR-21-5p mimics could promote cell proliferation, migration, and invasion of ASPC-1, as well as decrease the expression of B cell translocation gene 2. Curcumin treatment inhibited cell proliferation, migration and invasion of ASPC-1, as well as increased the expression of B cell translocation gene 2. MiR-21-5p could reverse the inhibitory activities of curcumin on ASPC-1 cell proliferation, migration, and invasion. In conclusion, curcumin is capable of inhibiting the proliferation, migration and invasion of pancreatic cancer cells via down-regulating miR-21-5p-mediated B cell translocation gene 2.
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