化学
氰化
烷基
镍
碘化物
催化作用
小学(天文学)
组合化学
有机化学
天文
物理
作者
Aiyou Xia,Peizhuo Lv,Xin Xie,Yuanhong Liu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2020-10-02
卷期号:22 (20): 7842-7847
被引量:9
标识
DOI:10.1021/acs.orglett.0c02722
摘要
Cyanation of unactivated primary and secondary alkyl mesylates with Zn(CN)2 catalyzed by nickel has been developed. The reaction provides an efficient route for the synthesis of alkyl nitriles with wide substrate scope, good functional group tolerance, and compatibility with heterocyclic compounds. Mechanistic studies indicate that alkyl iodide generated in situ serves as the reactive intermediate and the gradual release of alkyl iodide is crucial for the success of the reaction.
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