慢性炎症性脱髓鞘性多发性神经病
自身抗体
医学
抗体
免疫学
多发性神经病
多神经根神经病
静脉注射免疫球蛋白
病理
格林-巴利综合征
作者
Xuli Zhang,Peibing Zheng,Jérôme Devaux,Yan Wang,Chen Liu,Jing Li,Shougang Guo,Yan Song,Qian Wang,Xungang Feng,Yu‐Zhong Wang
标识
DOI:10.1016/j.jneuroim.2019.577074
摘要
Patients with chronic inflammatory demyelinating polyneuropathy (CIDP) seropositive for autoantibodies against nodal and paranodal proteins display distinct clinical presentations. We herein tested for autoantibodies against neurofascin (NF) 155, NF186, contactin-associated protein 1 and contactin-1 and investigated the autoantibody-related clinical features in 29 patients with CIDP from China. Six patients with anti-NF155 IgG4 antibodies displayed younger age of onset and poor response to intravenous immunoglobulin than seronegative patients. One patient had anti-NF186 IgG antibody and no patients had anti-contactin-associated protein 1 or anti-contactin-1 antibodies. Clinical features of CIDP patients with anti-NF155 antibodies in China were similar to those reported in other countries.
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