余辉
发光
体内
临床前影像学
持续发光
化学
材料科学
光电子学
生物
天文
伽马射线暴
热释光
物理
生物技术
作者
Luyan Wu,Yusuke Ishigaki,Yuxuan Hu,Keisuke Sugimoto,Wenhui Zeng,Takashi Harimoto,Yidan Sun,Jian He,Takanori Suzuki,Xiqun Jiang,Hong‐Yuan Chen,Deju Ye
标识
DOI:10.1038/s41467-020-14307-y
摘要
Abstract Afterglow luminescent probes with high signal-to-background ratio show promise for in vivo imaging; however, such probes that can be selectively delivered into target sites and switch on afterglow luminescence remain limited. We optimize an organic electrochromic material and integrate it into near-infrared (NIR) photosensitizer (silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) and (poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene]) containing nanoparticles, developing an H 2 S-activatable NIR afterglow probe ( F1 2+ -ANP). F1 2+ -ANP displays a fast reaction rate (1563 ± 141 M −1 s −1 ) and large afterglow turn-on ratio (~122-fold) toward H 2 S, enabling high-sensitivity and -specificity measurement of H 2 S concentration in bloods from healthy persons, hepatic or colorectal cancer patients. We further construct a hepatic-tumor-targeting and H 2 S-activatable afterglow probe ( F1 2+ -ANP-Gal) for noninvasive, real-time imaging of tiny subcutaneous HepG2 tumors (<3 mm in diameter) and orthotopic liver tumors in mice. Strikingly, F1 2+ -ANP-Gal accurately delineates tumor margins in excised hepatic cancer specimens, which may facilitate intraoperative guidance of hepatic cancer surgery.
科研通智能强力驱动
Strongly Powered by AbleSci AI