纹状体
医学
帕金森病
尾状核
多巴胺
单胺类神经递质
内科学
多巴胺能
囊泡单胺转运体
多巴胺转运体
帕金森病
壳核
内分泌学
疾病
再摄取
血清素
左旋多巴
胃肠病学
受体
作者
Xinchong Shi,Yan Zhang,Shaohua Xu,Hank F. Kung,Hongwen Qiao,Lu-lu Jiang,Lin Zhu,Qiyi Guo,Chang Yi,Ganhua Luo,Lei Wu,Zhong Pei,Jing Wang,Xiangsong Zhang,Ling Chen
出处
期刊:Clinical Nuclear Medicine
[Ovid Technologies (Wolters Kluwer)]
日期:2019-09-01
卷期号:44 (9): 707-713
被引量:12
标识
DOI:10.1097/rlu.0000000000002664
摘要
Nonmotor symptoms (NMS) are critical players in the patients' quality of life in Parkinson disease (PD). Vesicular monoamine transporter type 2 (VMAT2) has been reported owing to a role in affecting dopamine neurons in the striatum. Therefore, this study set out to characterize the relationship between VMAT2 distribution in the striatum in relation to the NMS in PD.Totally, 21 age-matched normal controls and 37 patients with PD in the moderate stages were included, followed by examination using F-DTBZ (F-AV133) PET/CT. The specific uptake ratio (SUR) of each striatal subregion was then determined with the occipital cortex as the reference background region. The overall NMSs of each individual patient were evaluated. Finally, the role of the striatal SURs in the clinical symptom scores were evaluated through the application of a Spearman correlation analysis as well as a multivariable stepwise regression analysis.Patients with PD, particularly those at a more advanced stage, exhibited a more pronounced reduction in SURs in the bilateral putamen and caudate nucleus (P < 0.05, vs healthy controls). Meanwhile, patients at more advanced PD stages were found to have significantly worse scores in NMS except cognitive function. The Spearman correlation analysis demonstrated that NMS scores, with the exception of cognition scores, were correlated with striatal SURs (P < 0.05).The key findings of the study identified a correlation between decreased striatal VMAT2 with a broad spectrum of NMS in patients with PD, highlighting the association between diminished dopamine supply and the development of NMS in PD.
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