胞质分裂
劈理沟
肌动蛋白
肌球蛋白
福明
细胞分裂
细胞生物学
劈理(地质)
生物
蛋白质丝
菲拉明
化学
生物物理学
细胞骨架
细胞
肌动蛋白细胞骨架
生物化学
古生物学
断裂(地质)
作者
Thomas D. Pollard,Ben O’Shaughnessy
标识
DOI:10.1146/annurev-biochem-062917-012530
摘要
Division of amoebas, fungi, and animal cells into two daughter cells at the end of the cell cycle depends on a common set of ancient proteins, principally actin filaments and myosin-II motors. Anillin, formins, IQGAPs, and many other proteins regulate the assembly of the actin filaments into a contractile ring positioned between the daughter nuclei by different mechanisms in fungi and animal cells. Interactions of myosin-II with actin filaments produce force to assemble and then constrict the contractile ring to form a cleavage furrow. Contractile rings disassemble as they constrict. In some cases, knowledge about the numbers of participating proteins and their biochemical mechanisms has made it possible to formulate molecularly explicit mathematical models that reproduce the observed physical events during cytokinesis by computer simulations.
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