益生元
普氏粪杆菌
肠道菌群
丁酸盐
拟杆菌
双歧杆菌
生物
丙酸盐
微生物学
乳酸菌
发酵
细菌
食品科学
生物化学
遗传学
作者
Sabina Leanti La Rosa,Vasiliki Kachrimanidou,Fanny Buffetto,Phillip B. Pope,Nicholas A. Pudlo,Eric C. Martens,Robert A. Rastall,Glenn R. Gibson,Bjørge Westereng
出处
期刊:mSphere
[American Society for Microbiology]
日期:2019-02-27
卷期号:4 (1)
被引量:47
标识
DOI:10.1128/msphere.00554-18
摘要
The architecture of the gut bacterial ecosystem has a profound effect on the physiology and well-being of the host. Modulation of the gut microbiota and the intestinal microenvironment via administration of prebiotics represents a valuable strategy to promote host health. This work provides insights into the ability of two novel wood-derived preparations, AcGGM and AcAGX, to influence human gut microbiota composition and activity. These compounds were selectively fermented by commensal bacteria such as Bifidobacterium , Bacteroides - Prevotella , F. prausnitzii , and clostridial cluster IX spp. This promoted the microbial synthesis of acetate, propionate, and butyrate, which are beneficial to the microbial ecosystem and host colonic epithelial cells. Thus, our results demonstrate potential prebiotic properties for both AcGGM and AcAGX from lignocellulosic feedstocks. These findings represent pivotal requirements for rationally designing intervention strategies based on the dietary supplementation of AcGGM and AcAGX to improve or restore gut health.
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