Noncoding RNAs in Muscle Atrophy

Denervation, disuse, fasting, and various diseases could induce skeletal muscle atrophy, which results in the decline of life quality and increase of the mortality risk for patients. Noncoding RNAs (ncRNAs) are implicated important in regulating gene expression. Thus, ncRNAs, especially microRNAs and long noncoding RNAs (lncRNAs), have gained widespread attention as crucial players in numerous physiological and pathological processes, including skeletal muscle atrophy. In this review, we comprehensively described the potential of circulating microRNAs as biomarkers, summarized the profiling of microRNAs and lncRNAs in atrophying muscles, as well as discussed the effects and underlying mechanisms of microRNA machinery proteins, microRNAs, and lncRNAs in skeletal muscle atrophy. Considering the large quantity and variety of ncRNAs, the understanding of ncRNAs in muscle atrophy is still very limited. Future studies are needed to elucidate the possibility of ncRNAs as diagnosis biomarkers and therapeutic targets in muscle atrophy.