纳米医学
药品
药物输送
化学
米托蒽醌
癌症治疗
体内
纳米技术
药理学
组合化学
纳米颗粒
癌症
材料科学
医学
化疗
有机化学
外科
生物技术
内科学
生物
作者
Shichao Wu,Shuo Hu,Xiangrui Yang
标识
DOI:10.3389/fbioe.2022.945148
摘要
The strategy for dual drug-loaded nanomedicine with targeting properties was always complex. Herein, a novel strategy for the preparation of metal-organic particle-based nanomedicine has been developed, and combretastatin A4 (CA4) and mitoxantrone (MIT) loaded MOPs (CMMOPs) have been obtained. In this system, using merely Cu(II) as a bridge to connect and coordinate with the dual drugs has resulted in the CMMOPs possessing a fairly high drug load of almost 90%. Moreover, the coordination between Cu(II) and the drugs was stable at physiological pH but easily cleavable in the tumor acidic microenvironment, which would provide a good targeting property for CMMOPs. The in vivo experiments indicated that CMMOPs possessed a significantly enhanced antitumor efficiency with negligible side effects. The results suggest that CMMOPs could be a potential anticancer formulation for tumor-targeted drug delivery.
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