微生物群
免疫系统
免疫学
流式细胞术
肠道微生物群
生物
肠道菌群
癌症研究
结直肠癌
癌症
生物信息学
遗传学
作者
Vrishketan Sethi,Saba Kurtom,Mohd Tarique,Shweta Lavania,Zoe X. Malchiodi,Leonor Hellmund,Li Zhang,Umakant Sharma,Bhuwan Giri,Bharti Garg,Anthony Ferrantella,Selwyn M. Vickers,Sulagna Banerjee,Rajinder Dawra,Sabita Roy,Sundaram Ramakrishnan,Ashok K. Saluja,Vikas Dudeja
标识
DOI:10.1053/j.gastro.2018.04.001
摘要
We studied the effects of gut microbiome depletion by oral antibiotics on tumor growth in subcutaneous and liver metastases models of pancreatic cancer, colon cancer, and melanoma. Gut microbiome depletion significantly reduced tumor burden in all the models tested. However, depletion of gut microbiome did not reduce tumor growth in Rag1-knockout mice, which lack mature T and B cells. Flow cytometry analyses demonstrated that gut microbiome depletion led to significant increase in interferon gamma-producing T cells with corresponding decrease in interleukin 17A and interleukin 10-producing T cells. Our results suggest that gut microbiome modulation could emerge as a novel immunotherapeutic strategy.
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