干血
干血斑
背景(考古学)
生物流体
医学
治疗药物监测
采样(信号处理)
临床实习
血液取样
医学物理学
计算机科学
重症监护医学
药品
药理学
化学
内科学
色谱法
生物
家庭医学
古生物学
滤波器(信号处理)
计算机视觉
作者
Gwenaël Nys,Miranda Kok,Anne-Catherine Servais,Marianne Fillet
标识
DOI:10.1016/j.trac.2017.10.002
摘要
Dried blood spot (DBS) has been used for more than 50 years for the screening of inborn errors of metabolism in newborns. Although DBS has remained the standard approach for most applications for many years, alternative sampling tools have been developed in parallel in attempts to overcome some of the well-described limitations of DBS. These alternatives were developed to accurately collect microliters of blood (typically 5–30 μl) in the least invasive way possible. In this review, three novel microsampling devices (dried plasma spots, capillary microsampling and volumetric absorptive microsampling) are compared to DBS and conventional plasma sampling. Covered domains include omics fields, pre-clinical studies, diagnosis, patient care (via therapeutic drug monitoring) and forensic toxicology. Specific advantages and limitations of each technique are presented for the different disciplines and perspectives for these promising technologies are discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI