医学
急性胰腺炎
血浆置换术
高甘油三酯血症
胃肠病学
内科学
回顾性队列研究
胰腺炎
妊娠期
高脂血症
甘油三酯
怀孕
入射(几何)
病因学
全身炎症反应综合征
外科
内分泌学
糖尿病
免疫学
胆固醇
抗体
败血症
物理
光学
生物
遗传学
作者
Chen Huang,Jie Liu,Yingying Lǚ,Junjie Fan,Xingpeng Wang,Jun Liu,Wei Zhang,Yue Zeng
摘要
Aim : To analyze the features and treatment of hypertriglyceridemia‐induced acute pancreatitis (HTGP) during pregnancy. Methods : A retrospective study of 21 pregnant women diagnosed with acute pancreatitis (AP) was performed. Patients were divided into acute biliary pancreatitis (ABP), HTGP, and idiopathic groups according to etiology. Results : 95% of the patients were in the third trimester of gestation. The percentage of patients with HTGP was higher than that of ABP (48% vs.14%). The percentage of severe acute pancreatitis (SAP) in the HTGP group was higher than that in the ABP group (40.0% vs.0%). The Ranson scores for moderately severe acute pancreatitis (MSAP) and SAP in the HTGP group were significantly different (2.50 ± 0.58 vs.3.60 ± 0.89, P < 0.05, respectively). The mean serum triglyceride (TG) levels in the MSAP and SAP HTGP groups were not significantly different (18.81 ± 11.13 vs. 30.53 ± 24.20 mmol/L, P > 0.05, respectively). In the HTGP group, there were five patients given plasma exchange therapy and five not. Plasmapheresis decreased the incidence of systemic inflammatory response syndrome (SIRS) from 100% to 28.6% and the TG level from 20.36 ± 7.41 mmol/L to 5.23 ± 3.62 mmol/L ( P < 0.05). The length of hospitalization of the plasmapheresis group was shorter than that of the nonplasmapheresis group (17.3 ± 6.7 days vs. 37.0 ± 20.8 days). Conclusions : Plasma exchange may be safe and effectively administered for HTGP patients during pregnancy with SIRS or multiple organ dysfunction syndrome (MODS). J. Clin. Apheresis 31:571–578, 2016. © 2015 Wiley Periodicals, Inc.
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