医学
灾难性抗磷脂综合征
治疗性血浆置换
暴发型
抗体
抗磷脂综合征
免疫学
内科学
胃肠病学
作者
Rachel Flamholz,Thuy B. Tran,Gary Grad,Ann M. Mauer,Olufunmilayo I. Olopade,Michael H. Ellman,James F. McKinsey,Hyeran Helen Jeon,Joseph M. Baron,Beverly W. Baron
标识
DOI:10.1002/(sici)1098-1101(1999)14:4<171::aid-jca3>3.0.co;2-5
摘要
We describe two patients with the catastrophic antiphospholipid syndrome associated with elevation of beta(2)-glycoprotein I antibodies and fulminant thrombotic diatheses. Both patients were treated with therapeutic plasma exchange (TPE), which resulted in a marked decrease in antibody titer accompanied by an improved clinical outcome in one patient (IgG antibody). In the second patient, the outcome was poor despite TPE (IgA antibody). There were no significant complications of TPE in either case. Because of the fulminant nature of the catastrophic antiphospholipid syndrome, we conclude that a trial of TPE is warranted for the acute management. Further studies are needed to clarify which patients may benefit from this treatment.
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