骨保护素
骨质疏松症
医学
疾病
更年期
内科学
病理生理学
机制(生物学)
生物信息学
内分泌学
受体
生理学
激活剂(遗传学)
生物
认识论
哲学
作者
Stefano Lello,Anna Capozzi,Giovanni Scambia
标识
DOI:10.3109/09513590.2015.1041908
摘要
Osteoporosis (OP) and cardiovascular diseases (CVD) are the most important causes of mortality and morbility in the elderly. Lots of studies showed a correlation between bone loss and cardiovascular risk mediated by the vascular calcification. The relationship between OP and CVD could be firstly explained by their common risk factors such as age, smoking, alcohol consumption, physical activity and menopause. However, other different hypotheses were proposed to clarify this link. Multiple factors, for example bone morphogenetic proteins, osteoprotegerin, receptor activator of nuclear factor κB ligand, parathyroid hormone, phosphate, oxidized lipids and vitamins D and K seemed to be involved in both conditions, indicating a possible common pathophysiologic mechanism. We review and discuss the available data describing this association. Further studies are necessary to better investigate similarities between OP and CVD.
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