医学
神秘的
涎腺癌
转移
癌症
肿瘤科
恶性肿瘤
内科学
病理
阶段(地层学)
唾液腺
病态的
生物
古生物学
替代医学
作者
Eve Tranchito,Claudia I. Cabrera,M. C. Terry,Shawn Li,Jason Thuener,Nicole Fowler,Pierre Lavertu,Theodoros N. Teknos,Rod Rezaee,Akina Tamaki
出处
期刊:Oral Oncology
[Elsevier]
日期:2022-05-01
卷期号:128: 105829-105829
被引量:2
标识
DOI:10.1016/j.oraloncology.2022.105829
摘要
Malignant salivary gland tumors are rare neoplasms that are vastly heterogenous in their histological patterns and clinical behaviors. As a consequence, studies have lacked the robust sample sizes needed to define treatment strategies. In this study, we used the National Cancer Database to identify the incidence of occult nodal metastasis and effect on overall survival for the most common malignant salivary gland subtypes. A retrospective review of patients in the National Cancer Database with primary site malignancies of major salivary glands between 2004 and 2016 was performed. Subjects included in the study underwent surgical treatment with and without adjuvant radiation and had complete information on TNM pathological stage.8,689 patients with primary malignant salivary gland cancer were analyzed. The sample was stratified by histologic subtype. Univariate analysis of lymph node metastasis of the whole cohort showed a higher risk of death (p < 0.001), when compared to those without. Also when comparing occult vs evident metastasis, the risk of death was higher for the latter (p < 0.001).Occult cervical lymph node metastasis ranged from 14.9% to 35.8% in malignant salivary gland cancers, depending on histological subtype. Occult nodal metastasis was a poor prognostic factor with significantly worse overall survival.
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