细胞毒性
真菌
立体化学
曲霉
海洋真菌
花色曲霉
细胞毒性T细胞
体外
生物
IC50型
化学
微生物学
生物化学
植物
作者
Zhaoming Liu,Saini Li,Yuchan Chen,Mingqiong Li,Hongxin Liu,Weimin Zhang
标识
DOI:10.1080/14786419.2021.2015595
摘要
Six globoscin derivatives (1‒6) including two new ones fischerins A (1) and B (2) were isolated from the deep-sea-derived fungus Aspergillus fischeri FS452. Their structures were elucidated by comprehensive spectroscopic analysis and the absolute configurations were determined by the quantum chemical ECD calculations. The in vitro cytotoxicity assays indicated that fischerin B (2) exhibited potential activities against the four tested human cancer cell lines (SF-268, MCF-7, HepG-2 and A549) with the IC50 values in the range of 7–10 µM.
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