荧光
检出限
猝灭(荧光)
化学
量子产额
硫黄
碳纤维
柠檬酸
氮气
量子点
分析化学(期刊)
色谱法
材料科学
纳米技术
有机化学
复合数
物理
复合材料
量子力学
作者
Shymaa M. Abd Elhaleem,Fawzi Elsebaei,Sh. Shalan,Fathalla Belal
标识
DOI:10.1016/j.saa.2022.120954
摘要
Nitrogen and sulfur carbon quantum dots(N,S-CQDs) as effective fluorescent nanoprobes were synthesized through one-step-hydrothermal method using thiosemicarbazide (as nitrogen and sulfur source) and citric acid (as carbon source). The highly fluorescent N,S-CQDs were subjected to various characterization techniques. The fluorescence of the synthesized N,S-CQDs is characterized by maximum fluorescence emission at 415 nm after excitation at 345 nm and a high quantum yield of 0.58. The native N,S-CQDs fluorescence is quantitatively quenched upon addition of imatinib (IMA), so they are used for its spectrofluorimetric determination in its pharmaceutical formulations and biological fluids. Under optimal conditions, N,S-CQDs exhibited a "turn-off" fluorescence response to IMA over the range of 1.0 to 15.0 µg/mL with a limit of quantification of 0.42 µg/mL and a lower detection limit of 0.14 µg/mL. Stern-Volmer equation was used to study the mechanism of quenching and it was found to occur through static quenching mechanism. The method was extended to the in-vitro determination of the drug in spiked human urine and plasma samples and the percent recoveries were satisfactory.
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