乙型肝炎表面抗原
乙型肝炎病毒
血清学
表面增强拉曼光谱
医学
乙型肝炎
病毒学
血清
病毒
拉曼光谱
内科学
抗体
免疫学
拉曼散射
光学
物理
作者
Zuci Zheng,Qiwen Wang,Cuncheng Weng,Xueliang Lin,Yao Lin,Shouhua Feng
摘要
An optical method of surface-enhanced Raman spectroscopy (SERS) was developed for non-invasive detection of hepatitis B surface virus (HBV). Hepatitis B virus surface antigen (HBsAg) is an established serological marker that is routinely used for the diagnosis of acute or chronic hepatitis B virus(HBV) infection. Utilizing SERS to analyze blood serum for detecting HBV has not been reported in previous literature. SERS measurements were performed on two groups of serum samples: one group for 50 HBV patients and the other group for 50 healthy volunteers. Blood serum samples are collected from healthy control subjects and patients diagnosed with HBV. Furthermore, principal components analysis (PCA) combined with linear discriminant analysis (LDA) were employed to differentiate HBV patients from healthy volunteer and achieved sensitivity of 80.0% and specificity of 74.0%. This exploratory work demonstrates that SERS serum analysis combined with PCA-LDA has tremendous potential for the non-invasive detection of HBV.
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