医学
肝移植
移植
肝衰竭
信号转导
慢性肝病
器官移植
肝病
生物信息学
疾病
程序性细胞死亡
重症监护医学
免疫学
内科学
生物
细胞生物学
细胞凋亡
肝硬化
生物化学
作者
Liqiao Huang,Jie Liu,Caiqun Bie,Helu Liu,Yichun Ji,Dongfeng Chen,Meiling Zhu,Weihong Kuang
标识
DOI:10.1016/j.clinre.2021.101783
摘要
Acute-on-chronic liver failure (ACLF) has been a hot spot in the field of liver disease research in recent years, with high morbidity, rapid course change and high mortality. Currently, there is the absence of specific treatment in clinical practice. Liver transplantation has the best therapeutic effect, but it is prone to have internal environment disorder and liver cell death after transplantation, which leads to the failure of transplantation.In recent years, with the development of molecular biology, scholars have explored the treatment of ACLF at the molecular level, and more and more molecular signaling pathways related to the treatment of ACLF have been discovered. Modulating the relevant signaling pathways to reduce the mortality of liver cells after transplantation may effectively improve the success rate of transplantation. In this review, we introduce some signaling pathways related to cell death and their research progress in acute-on-chronic liver failure.
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