生物正交化学
化学
生化工程
生物催化
催化作用
组合化学
纳米技术
计算机科学
有机化学
工程类
点击化学
反应机理
材料科学
作者
Paul Ebensperger,Claudia Jessen‐Trefzer
标识
DOI:10.1515/hsz-2021-0329
摘要
Artificial metalloenzymes combine the inherent reactivity of transition metal catalysis with the sophisticated reaction control of natural enzymes. By providing new opportunities in bioorthogonal chemistry and biocatalysis, artificial metalloenzymes have the potential to overcome certain limitations in both drug discovery and green chemistry or related research fields. Ongoing advances in organometallic catalysis, directed evolution, and bioinformatics are enabling the design of increasingly powerful systems that outperform conventional catalysis in a growing number of cases. Therefore, this review article collects challenges and opportunities in designing artificial metalloenzymes described in recent review articles. This will provide an equitable insight for those new to and interested in the field.
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